CCK-58 elicits both satiety and satiation in rats while CCK-8 elicits only satiation
نویسندگان
چکیده
منابع مشابه
Sweetness, satiation, and satiety.
Satiation and satiety are central concepts in the understanding of appetite control and both have to do with the inhibition of eating. Satiation occurs during an eating episode and brings it to an end. Satiety starts after the end of eating and prevents further eating before the return of hunger. Enhancing satiation and satiety derived from foodstuffs was perceived as a means to facilitate weig...
متن کاملCCK - 8 and CCK - 58 differ in their effects on nocturnal solid meal 1 pattern in undisturbed rats
26 Various molecular forms of cholecystokinin (CCK) reduce food intake in rats. Although CCK-8 is the 27 most studied form, we reported that CCK-58 is the only detectable endocrine peptide form in rats. We 28 investigated the dark phase rat chow intake pattern following injection of CCK-8 and CCK-58. Ad libitum 29 fed male Sprague-Dawley rats were intraperitoneally injected with CCK-8, CCK-58 (...
متن کاملCCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed rats.
Various molecular forms of CCK reduce food intake in rats. Although CCK-8 is the most studied form, we reported that CCK-58 is the only detectable endocrine peptide form in rats. We investigated the dark-phase rat chow intake pattern following injection of CCK-8 and CCK-58. Ad libitum-fed male Sprague-Dawley rats were intraperitoneally injected with CCK-8, CCK-58 (0.6, 1.8, and 5.2 nmol/kg), or...
متن کاملDifferential bile-pancreatic secretory effects of CCK-58 and CCK-8.
In this work, we 1) synthesized rat CCK-58, 2) determined the amounts and forms of rat CCK in whole blood after stimulation of its release by casein, 3) determined the potency of CCK-8 and CCK-58 peptides to displace labeled CCK-8 from CCK(A) and CCK(B) receptors transfected into Chinese hamster ovary (CHO) cells, and 4) examined the biological actions of CCK-8 and rat CCK-58 in an anesthetized...
متن کاملComparison of CCK-8 receptors in the pancreas and brain of rats using CCK-8 analogues.
The characteristics of cholecystokinin (CCK) receptors in rat pancreatic acini and in various regions of the brain were examined using synthetic CCK-8 or CCK-7 analogues. 3H-propionylated CCK-8 [( 3H]CCK-8) was used as a ligand. 1) The pancreatic CCK receptor had a single high affinity binding component with a dissociation constant, Kd, of 0.76 nM and a maximum number of specific binding sites,...
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ژورنال
عنوان ژورنال: Peptides
سال: 2014
ISSN: 0196-9781
DOI: 10.1016/j.peptides.2014.01.008